The BET Bromodomain Inhibitor I-BET151 Acts Downstream of Smoothened Protein to Abrogate the Growth of Hedgehog Protein-driven Cancers

Epigenetic enzymes modulate signal transduction pathways in different biological contexts. We reasoned that epigenetic regulators might modulate the Hedgehog (HH) signaling pathway, a main driver of cell proliferation in various cancers including medulloblastoma. To test this hypothesis, we performe...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Long, Jun, Li, Bin, Rodriguez-Blanco, Jezabel, Pastori, Chiara, Volmar, Claude-Henry, Wahlestedt, Claes, Capobianco, Anthony, Bai, Feng, Pei, Xin-Hai, Ayad, Nagi G., Robbins, David J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4271234/
https://ncbi.nlm.nih.gov/pubmed/25355313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.595348
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