The Bromodomain protein BRD4 controls HOTAIR, a long noncoding RNA essential for glioblastoma proliferation

Bromodomain and extraterminal (BET) domain proteins have emerged as promising therapeutic targets in glioblastoma and many other cancers. Small molecule inhibitors of BET bromodomain proteins reduce expression of several oncogenes required for Glioblastoma Multiforme (GBM) progression. However, the...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Pastori, Chiara, Kapranov, Philipp, Penas, Clara, Peschansky, Veronica, Volmar, Claude-Henry, Sarkaria, Jann N., Bregy, Amade, Komotar, Ricardo, St. Laurent, Georges, Ayad, Nagi G., Wahlestedt, Claes
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4500283/
https://ncbi.nlm.nih.gov/pubmed/26111795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1424220112
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