The Bromodomain protein BRD4 controls HOTAIR, a long noncoding RNA essential for glioblastoma proliferation

Bromodomain and extraterminal (BET) domain proteins have emerged as promising therapeutic targets in glioblastoma and many other cancers. Small molecule inhibitors of BET bromodomain proteins reduce expression of several oncogenes required for Glioblastoma Multiforme (GBM) progression. However, the...

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Enregistré dans:
Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Pastori, Chiara, Kapranov, Philipp, Penas, Clara, Peschansky, Veronica, Volmar, Claude-Henry, Sarkaria, Jann N., Bregy, Amade, Komotar, Ricardo, St. Laurent, Georges, Ayad, Nagi G., Wahlestedt, Claes
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2015
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4500283/
https://ncbi.nlm.nih.gov/pubmed/26111795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1424220112
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