The Bromodomain protein BRD4 controls HOTAIR, a long noncoding RNA essential for glioblastoma proliferation

Bromodomain and extraterminal (BET) domain proteins have emerged as promising therapeutic targets in glioblastoma and many other cancers. Small molecule inhibitors of BET bromodomain proteins reduce expression of several oncogenes required for Glioblastoma Multiforme (GBM) progression. However, the...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Pastori, Chiara, Kapranov, Philipp, Penas, Clara, Peschansky, Veronica, Volmar, Claude-Henry, Sarkaria, Jann N., Bregy, Amade, Komotar, Ricardo, St. Laurent, Georges, Ayad, Nagi G., Wahlestedt, Claes
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2015
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4500283/
https://ncbi.nlm.nih.gov/pubmed/26111795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1424220112
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