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A G protein functions immediately downstream of Smoothened in Hedgehog signaling
The Hedgehog (Hh) signaling pathway plays an evolutionarily conserved role in patterning fields of cells during metazoan development, and is inappropriately activated in cancer1,2. Hh pathway activity is absolutely dependent upon signaling by the seven-transmembrane protein Smoothened (Smo), which i...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2008
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2744466/ https://ncbi.nlm.nih.gov/pubmed/18987629 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature07459 |
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