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An essential role for Grk2 in Hedgehog signalling downstream of Smoothened
The G‐protein‐coupled receptor kinase 2 (adrbk2/GRK2) has been implicated in vertebrate Hedgehog (Hh) signalling based on the effects of its transient knock‐down in mammalian cells and zebrafish embryos. Here, we show that the response to Hh signalling is effectively abolished in the absence of Grk2...
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| Pubblicato in: | EMBO Rep |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
John Wiley and Sons Inc.
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5341524/ https://ncbi.nlm.nih.gov/pubmed/27113758 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201541532 |
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