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An essential role for Grk2 in Hedgehog signalling downstream of Smoothened
The G‐protein‐coupled receptor kinase 2 (adrbk2/GRK2) has been implicated in vertebrate Hedgehog (Hh) signalling based on the effects of its transient knock‐down in mammalian cells and zebrafish embryos. Here, we show that the response to Hh signalling is effectively abolished in the absence of Grk2...
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| Publicado no: | EMBO Rep |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5341524/ https://ncbi.nlm.nih.gov/pubmed/27113758 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201541532 |
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