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A Smoothened-Evc2 Complex Transduces the Hedgehog Signal at Primary Cilia
Vertebrate Hedgehog (Hh) signaling is initiated at primary cilia by the ligand-triggered accumulation of Smoothened (Smo) in the ciliary membrane. The underlying biochemical mechanisms remain unknown. We find that Hh agonists promote the association between Smo and Evc2, a ciliary protein that is de...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3586260/ https://ncbi.nlm.nih.gov/pubmed/22981989 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2012.07.004 |
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