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A Smoothened-Evc2 Complex Transduces the Hedgehog Signal at Primary Cilia

Vertebrate Hedgehog (Hh) signaling is initiated at primary cilia by the ligand-triggered accumulation of Smoothened (Smo) in the ciliary membrane. The underlying biochemical mechanisms remain unknown. We find that Hh agonists promote the association between Smo and Evc2, a ciliary protein that is de...

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Main Authors: Dorn, Karolin V., Hughes, Casey E., Rohatgi, Rajat
格式: Artigo
語言:Inglês
出版: 2012
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3586260/
https://ncbi.nlm.nih.gov/pubmed/22981989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2012.07.004
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