EFCAB7 and IQCE regulate Hedgehog signaling by tethering the EVC-EVC2 complex to the base of primary cilia

The Hedgehog (Hh) pathway depends on primary cilia in vertebrates, but the signaling machinery within cilia remains incompletely defined. We report the identification of a complex between two ciliary proteins, EFCAB7 and IQCE, which positively regulates the Hh pathway. The EFCAB7-IQCE module anchors...

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Hlavní autoři: Pusapati, Ganesh V., Hughes, Casey E, Dorn, Karolin V., Zhang, Dapeng, Sugianto, Priscilla, Aravind, L., Rohatgi, Rajat
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027042/
https://ncbi.nlm.nih.gov/pubmed/24582806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2014.01.021
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