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A membrane-tethered ubiquitination pathway regulates Hedgehog signaling and heart development
The etiology of congenital heart defects (CHDs), amongst the most common human birth defects, is poorly understood because of its complex genetic architecture. Here we show that two genes implicated in CHDs, Megf8 and Mgrn1, interact genetically and biochemically to regulate the strength of Hedgehog...
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| Yayımlandı: | Dev Cell |
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| Asıl Yazarlar: | , , , , , , , , , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2020
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7686252/ https://ncbi.nlm.nih.gov/pubmed/32966817 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2020.08.012 |
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