A membrane-tethered ubiquitination pathway regulates Hedgehog signaling and heart development

The etiology of congenital heart defects (CHDs), amongst the most common human birth defects, is poorly understood because of its complex genetic architecture. Here we show that two genes implicated in CHDs, Megf8 and Mgrn1, interact genetically and biochemically to regulate the strength of Hedgehog...

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Detaylı Bibliyografya
Yayımlandı:Dev Cell
Asıl Yazarlar: Kong, Jennifer H., Young, Cullen B., Pusapati, Ganesh V., Patel, Chandni B., Ho, Sebastian, Krishnan, Arunkumar, Ivy Lin, Jiuann-Huey, Devine, William, Moreau de Bellaing, Anne, Athni, Tejas S., Aravind, L., Gunn, Teresa M., Lo, Cecilia W., Rohatgi, Rajat
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2020
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7686252/
https://ncbi.nlm.nih.gov/pubmed/32966817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2020.08.012
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