A membrane-tethered ubiquitination pathway regulates Hedgehog signaling and heart development

The etiology of congenital heart defects (CHDs), amongst the most common human birth defects, is poorly understood because of its complex genetic architecture. Here we show that two genes implicated in CHDs, Megf8 and Mgrn1, interact genetically and biochemically to regulate the strength of Hedgehog...

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Detalhes bibliográficos
Publicado no:Dev Cell
Main Authors: Kong, Jennifer H., Young, Cullen B., Pusapati, Ganesh V., Patel, Chandni B., Ho, Sebastian, Krishnan, Arunkumar, Ivy Lin, Jiuann-Huey, Devine, William, Moreau de Bellaing, Anne, Athni, Tejas S., Aravind, L., Gunn, Teresa M., Lo, Cecilia W., Rohatgi, Rajat
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7686252/
https://ncbi.nlm.nih.gov/pubmed/32966817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2020.08.012
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