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Multiple ligand binding sites regulate the Hedgehog signal transducer Smoothened in vertebrates

The Hedgehog (Hh) pathway plays a central role in the development of multicellular organisms, guiding cell differentiation, proliferation and survival. While many components of the vertebrate pathway were discovered two decades ago, the mechanism by which the Hh signal is transmitted across the plas...

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Veröffentlicht in:Curr Opin Cell Biol
Hauptverfasser: Byrne, Eamon FX, Luchetti, Giovanni, Rohatgi, Rajat, Siebold, Christian
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5949240/
https://ncbi.nlm.nih.gov/pubmed/29268141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ceb.2017.10.004
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