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Cholesterol activates the G-protein coupled receptor Smoothened to promote Hedgehog signaling
Cholesterol is necessary for the function of many G-protein coupled receptors (GPCRs). We find that cholesterol is not just necessary but also sufficient to activate signaling by the Hedgehog (Hh) pathway, a prominent cell-cell communication system in development. Cholesterol influences Hh signaling...
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| Udgivet i: | eLife |
|---|---|
| Main Authors: | , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
eLife Sciences Publications, Ltd
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5123864/ https://ncbi.nlm.nih.gov/pubmed/27705744 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.20304 |
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