Cholesterol activates the G-protein coupled receptor Smoothened to promote Hedgehog signaling

Cholesterol is necessary for the function of many G-protein coupled receptors (GPCRs). We find that cholesterol is not just necessary but also sufficient to activate signaling by the Hedgehog (Hh) pathway, a prominent cell-cell communication system in development. Cholesterol influences Hh signaling...

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Veröffentlicht in:eLife
Hauptverfasser: Luchetti, Giovanni, Sircar, Ria, Kong, Jennifer H, Nachtergaele, Sigrid, Sagner, Andreas, Byrne, Eamon FX, Covey, Douglas F, Siebold, Christian, Rohatgi, Rajat
Format: Artigo
Sprache:Inglês
Veröffentlicht: eLife Sciences Publications, Ltd 2016
Schlagworte:
Biochemistry
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5123864/
https://ncbi.nlm.nih.gov/pubmed/27705744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.20304
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