Structural basis for Smoothened regulation by its extracellular domains

Developmental signals of the Hedgehog (Hh) and Wnt families are transduced across the membrane by Frizzled-class G-protein coupled receptors (GPCRs) composed of both a heptahelical transmembrane domain (TMD) and an extracellular cysteine-rich domain (CRD). How such large extracellular domains of GPC...

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Vydáno v:Nature
Hlavní autoři: Byrne, Eamon F.X., Sircar, Ria, Miller, Paul S., Hedger, George, Luchetti, Giovanni, Nachtergaele, Sigrid, Tully, Mark D., Mydock-McGrane, Laurel, Covey, Douglas F., Rambo, Robert P., Sansom, Mark S. P., Newstead, Simon, Rohatgi, Rajat, Siebold, Christian
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4970916/
https://ncbi.nlm.nih.gov/pubmed/27437577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature18934
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