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Oxysterols are allosteric activators of the oncoprotein Smoothened

Oxysterols are a class of endogenous signaling molecules that can activate the Hedgehog pathway, which plays critical roles in development, regeneration and cancer. However, it has been unclear how oxysterols influence Hedgehog signaling, including whether their effects are mediated through a protei...

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Detalhes bibliográficos
Main Authors: Nachtergaele, Sigrid, Mydock, Laurel K., Krishnan, Kathiresan, Rammohan, Jayan, Schlesinger, Paul H., Covey, Douglas F., Rohatgi, Rajat
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3262054/
https://ncbi.nlm.nih.gov/pubmed/22231273
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.765
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