Cilia-associated oxysterols activate Smoothened

Primary cilia are required for Smoothened to transduce vertebrate Hedgehog signals, but how Smoothened accumulates in cilia and is activated is incompletely understood. Here, we identify cilia-associated oxysterols that promote Smoothened accumulation in cilia and activate the Hedgehog pathway. Our...

詳細記述

保存先:
書誌詳細
出版年:Mol Cell
主要な著者: Raleigh, David R., Sever, Navdar, Choksi, Pervinder K., Sigg, Monika Abedin, Hines, Kelly M., Thompson, Bonne M., Elnatan, Daniel, Jaishankar, Priyadarshini, Bisignano, Paola, Garcia-Gonzalo, Francesc R., Krup, Alexis Leigh, Eberl, Markus, Wong, Sunny Y., Renslo, Adam R., Grabe, Michael, McDonald, Jeffrey G., Xu, Libin, Beachy, Philip A., Reiter, Jeremy F.
フォーマット: Artigo
言語:Inglês
出版事項: 2018
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6503851/
https://ncbi.nlm.nih.gov/pubmed/30340023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.08.034
タグ: タグ追加
タグなし, このレコードへの初めてのタグを付けませんか!

類似資料