Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling

The Hedgehog (Hh) signal is transduced across the membrane by the heptahelical protein Smoothened (Smo), a developmental regulator, oncoprotein and drug target in oncology. We present the 2.3 Å crystal structure of the extracellular cysteine rich domain (CRD) of vertebrate Smo and show that it binds...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Nachtergaele, Sigrid, Whalen, Daniel M, Mydock, Laurel K, Zhao, Zhonghua, Malinauskas, Tomas, Krishnan, Kathiresan, Ingham, Philip W, Covey, Douglas F, Siebold, Christian, Rohatgi, Rajat
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: eLife Sciences Publications, Ltd 2013
Gaiak:
Biochemistry
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3809587/
https://ncbi.nlm.nih.gov/pubmed/24171105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.01340
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