Discovery of VU6005649, a CNS Penetrant mGlu(7/8) Receptor PAM Derived from a Series of Pyrazolo[1,5-a]pyrimidines

par Abe, Masahito, Seto, Mabel, Gogliotti, Rocco G., Loch, Matthew T., Bollinger, Katrina A., Chang, Sichen, Engelberg, Eileen M., Luscombe, Vincent B., Harp, Joel M., Bubser, Michael, Engers, Darren W., Jones, Carrie K., Rodriguez, Alice L., Blobaum, Anna L., Conn, P. Jeffrey, Niswender, Colleen M., Lindsley, Craig W.
Publié dans ACS Med Chem Lett (2017)

VU6010608, a Novel mGlu(7) NAM from a Series of N-(2-(1H-1,2,4-Triazol-1-yl)-5-(trifluoromethoxy)phenyl)benzamides

par Reed, Carson W., McGowan, Kevin M., Spearing, Paul K., Stansley, Branden J., Roenfanz, Hanna F., Engers, Darren W., Rodriguez, Alice L., Engelberg, Eileen M., Luscombe, Vincent B., Loch, Matthew T., Remke, Daniel H., Rook, Jerri M., Blobaum, Anna L., Conn, P. Jeffrey, Niswender, Colleen M., Lindsley, Craig W.
Publié dans ACS Med Chem Lett (2017)

Optimization of M(4) positive allosteric modulators (PAMs): The discovery of VU0476406, a non-human primate in vivo tool compound for translational pharmacology

par Melancon, Bruce J., Wood, Michael R., Noetzel, Meredith J., Nance, Kellie D., Engelberg, Eileen M., Han, Changho, Lamsal, Atin, Chang, Sichen, Cho, Hyekyung P., Byers, Frank W., Bubser, Michael, Jones, Carrie K., Niswender, Colleen M., Wood, Michael W., Engers, Darren W., Wu, Dedong, Brandon, Nicholas J., Duggan, Mark E., Conn, P. Jeffrey, Bridges, Thomas M., Lindsley, Craig W.
Publié dans Bioorg Med Chem Lett (2017)