VU6010608, a Novel mGlu(7) NAM from a Series of N-(2-(1H-1,2,4-Triazol-1-yl)-5-(trifluoromethoxy)phenyl)benzamides

[Image: see text] Herein, we report the structure–activity relationships within a series of mGlu(7) NAMs based on an N-(2-(1H-1,2,4-triazol-1-yl)-5-(trifluoromethoxy)phenyl)benzamide core with excellent CNS penetration (K(p) 1.9–5.8 and K(p,uu) 0.4–1.4). Analogues in this series displayed steep SAR....

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:ACS Med Chem Lett
Asıl Yazarlar: Reed, Carson W., McGowan, Kevin M., Spearing, Paul K., Stansley, Branden J., Roenfanz, Hanna F., Engers, Darren W., Rodriguez, Alice L., Engelberg, Eileen M., Luscombe, Vincent B., Loch, Matthew T., Remke, Daniel H., Rook, Jerri M., Blobaum, Anna L., Conn, P. Jeffrey, Niswender, Colleen M., Lindsley, Craig W.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Chemical Society 2017
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5733308/
https://ncbi.nlm.nih.gov/pubmed/29259756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00429
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller