Tumor cells engineered to codisplay on their surface 4-1BBL and LIGHT costimulatory proteins as a novel vaccine approach for cancer immunotherapy

Por Sharma, Rajesh Kumar, Yolcu, Esma S., Elpek, Kutlu G., Shirwan, Haval
Publicado em 2010

Mature natural killer cells with phenotypic and functional alterations accumulate upon sustained stimulation with IL-15/IL-15Rα complexes

Por Elpek, Kutlu G., Rubinstein, Mark P., Bellemare-Pelletier, Angelique, Goldrath, Ananda W., Turley, Shannon J.
Publicado em 2010

Diminished metastasis in tetraspanin CD151–knockout mice

Por Takeda, Yoshito, Li, Qinglin, Kazarov, Alexander R., Epardaud, Mathieu, Elpek, Kutlu, Turley, Shannon J., Hemler, Martin E.
Publicado em 2011

Costimulation as a platform for the development of vaccines: a peptide-based vaccine containing a novel form of 4-1BBL eradicates established tumors

Por Sharma, Rajesh K., Elpek, Kutlu G., Yolcu, Esma S., Schabowsky, Rich-Henry, Zhao, Hong, Bandura-Morgan, Laura, Shirwan, Haval
Publicado em 2009

Lymphoid Organ-Resident Dendritic Cells Exhibit Unique Transcriptional Fingerprints Based on Subset and Site

Por Elpek, Kutlu G., Bellemare-Pelletier, Angelique, Malhotra, Deepali, Reynoso, Erika D., Lukacs-Kornek, Veronika, DeKruyff, Rosemarie H., Turley, Shannon J.
Publicado em 2011

Regulated release of nitric oxide by nonhematopoietic stroma controls expansion of the activated T cell pool in lymph nodes

Por Lukacs-Kornek, Veronika, Malhotra, Deepali, Fletcher, Anne L, Acton, Sophie E, Elpek, Kutlu G, Tayalia, Prakriti, Collier, Ai-ris, Turley, Shannon J
Publicado em 2011

Intestinal Tolerance Is Converted to Autoimmune Enteritis upon PD-1 Ligand Blockade

Por Reynoso, Erika D., Elpek, Kutlu G., Francisco, Loise, Bronson, Roderick, Bellemare-Pelletier, Angélique, Sharpe, Arlene H., Freeman, Gordon J., Turley, Shannon J.
Publicado em 2009

The tumor microenvironment shapes lineage, transcriptional, and functional diversity of infiltrating myeloid cells

Por Elpek, Kutlu G., Cremasco, Viviana, Shen, Hua, Harvey, Christopher J., Wucherpfennig, Kai W, Goldstein, Daniel R., Monach, Paul A., Turley, Shannon J.
Publicado em 2014

A Novel Form of 4-1BBL Has Better Immunomodulatory Activity than an Agonistic Anti-4-1BB Ab without Ab Associated Severe Toxicity

Por Schabowsky, Rich-Henry, Elpek, Kutlu G, Madireddi, Shravan, Sharma, Rajesh K, Yolcu, Esma S., Bandura-Morgan, Laura, Miller, Robert, MacLeod, Kathryn J, Mittler, Robert S., Shirwan, Haval
Publicado em 2009

Efficacy of anti-ICOS agonist monoclonal antibodies in preclinical tumor models provides a rationale for clinical development as cancer immunotherapeutics

Por Harvey, Christopher, Elpek, Kutlu, Duong, Ellen, Simpson, Tyler, Shu, ChengYi J, Shallberg, Lindsey, Wallace, Matthew, Sathyanarayanan, Sriram, Mabry, Robert, Briskin, Michael, Michaelson, Jennifer, Gajewski, Thomas F
Publicado no J Immunother Cancer (2015)

4-1BB ligand as an effective multifunctional immunomodulator and antigen delivery vehicle for the development of therapeutic cancer vaccines

Por Sharma, Rajesh K., Schabowsky, Rich-Henry, Srivastava, Abhishek K., Elpek, Kutlu G., Madireddi, Shravan, Zhao, Hong, Zhong, Zhenping, Miller, Robert W., MacLeod, Kathryn J., Yolcu, Esma S., Shirwan, Haval
Publicado em 2010

IgE/FcεRI-mediated antigen cross-presentation by dendritic cells enhances anti-tumor immune responses

Por Platzer, Barbara, Elpek, Kutlu G., Cremasco, Viviana, Baker, Kristi, Stout, Madeleine M, Schultz, Cornelia, Dehlink, Eleonora, Shade, Kai-Ting C., Anthony, Robert M., Blumberg, Richard S., Turley, Shannon J., Fiebiger, Edda
Publicado no Cell Rep (2015)

Transcriptional profiling of stroma from inflamed and resting lymph nodes defines immunological hallmarks

Por Malhotra, Deepali, Fletcher, Anne L., Astarita, Jillian, Lukacs-Kornek, Veronika, Tayalia, Prakriti, Gonzalez, Santiago F., Elpek, Kutlu G., Chang, Sook Kyung, Knoblich, Konstantin, Hemler, Martin E., Brenner, Michael, Carroll, Michael C., Mooney, David J., Turley, Shannon J.
Publicado em 2012

Gene expression profiles and transcriptional regulatory pathways underlying mouse tissue macrophage identity and diversity

Por Gautier, Emmanuel L., Shay, Tal, Miller, Jennifer, Greter, Melanie, Jakubzick, Claudia, Ivanov, Stoyan, Helft, Julie, Chow, Andrew, Elpek, Kutlu G., Gordonov, Simon, Mazloom, Amin R., Ma’ayan, Avi, Chua, Wei-Jen, Hansen, Ted H., Turley, Shannon J., Merad, Miriam, Randolph, Gwendalyn J
Publicado em 2012

Deciphering the transcriptional network of the DC lineage

Por Miller, Jennifer C, Brown, Brian D., Shay, Tal, Gautier, Emmanuel L, Jojic, Vladimir, Cohain, Ariella, Pandey, Gaurav, Leboeuf, Marylene, Elpek, Kutlu G, Helft, Julie, Hashimoto, Daigo, Chow, Andrew, Price, Jeremy, Greter, Melanie, Bogunovic, Milena, Bellemare-Pelletier, Angelique, Frenette, Paul S., Randolph, Gwendalyn J., Turley, Shannon J., Merad, Miriam
Publicado em 2012

In vivo Discovery of Immunotherapy Targets in the Tumor Microenvironment

Por Zhou, Penghui, Shaffer, Donald R., Arias, Diana A. Alvarez, Nakazaki, Yukoh, Pos, Wouter, Torres, Alexis J., Cremasco, Viviana, Dougan, Stephanie K., Cowley, Glenn S., Elpek, Kutlu, Brogdon, Jennifer, Lamb, John, Turley, Shannon, Ploegh, Hidde L., Root, David E., Love, J. Christopher, Dranoff, Glenn, Hacohen, Nir, Cantor, Harvey, Wucherpfennig, Kai W.
Publicado em 2014

Podoplanin-Rich Stromal Networks Induce Dendritic Cell Motility via Activation of the C-type Lectin Receptor CLEC-2

Por Acton, Sophie E., Astarita, Jillian L., Malhotra, Deepali, Lukacs-Kornek, Veronika, Franz, Bettina, Hess, Paul R., Jakus, Zoltan, Kuligowski, Michael, Fletcher, Anne L., Elpek, Kutlu G., Bellemare-Pelletier, Angelique, Sceats, Lindsay, Reynoso, Erika D., Gonzalez, Santiago F., Graham, Daniel B., Chang, Jonathan, Peters, Anneli, Woodruff, Matthew, Kim, Young-A., Swat, Wojciech, Morita, Takashi, Kuchroo, Vijay, Carroll, Michael C., Kahn, Mark L., Wucherpfennig, Kai W., Turley, Shannon J.
Publicado em 2012

Pten is a major tumor suppressor in pancreatic ductal adenocarcinoma and regulates an NF-κB-cytokine network

Por Ying, Haoqiang, Elpek, Kutlu G., Vinjamoori, Anant, Zimmerman, Stephanie M., Chu, Gerald C., Yan, Haiyan, Fletcher-Sananikone, Eliot, Zhang, Hailei, Liu, Yingchun, Wang, Wei, Ren, Xiaojia, Zheng, Hongwu, Kimmelman, Alec C., Paik, Ji-hye, Lim, Carol, Perry, Samuel R., Jiang, Shan, Malinn, Brian, Protopopov, Alexei, Colla, Simona, Xiao, Yonghong, Hezel, Aram F., Bardeesy, Nabeel, Turley, Shannon J., Wang, Y. Alan, Chin, Lynda, Thayer, Sarah P., DePinho, Ronald A.
Publicado em 2011

Mutations in G protein beta subunits promote transformation and kinase inhibitor resistance

Por Yoda, Akinori, Adelmant, Guillaume, Tamburini, Jerome, Chapuy, Bjoern, Shindoh, Nobuaki, Yoda, Yuka, Weigert, Oliver, Kopp, Nadja, Wu, Shuo-Chieh, Kim, Sunhee S., Liu, Huiyun, Tivey, Trevor, Christie, Amanda L., Elpek, Kutlu G., Card, Joseph, Gritsman, Kira, Gotlib, Jason, Deininger, Michael W., Makishima, Hideki, Turley, Shannon J., Javidi-Sharifi, Nathalie, Maciejewski, Jaroslaw P., Jaiswal, Siddhartha, Ebert, Benjamin L., Rodig, Scott J., Tyner, Jeffrey W., Marto, Jarrod A., Weinstock, David M., Lane, Andrew A.
Publicado no Nat Med (2014)