A Novel Form of 4-1BBL Has Better Immunomodulatory Activity than an Agonistic Anti-4-1BB Ab without Ab Associated Severe Toxicity

Agonistic Abs to select costimulatory members of CD28 and TNFR family have shown efficacy in various preclinical cancer immunotherapeutic settings. However, the use of agonistic Abs is often associated with severe toxicity due to nonspecific activation of lymphocytes. We hypothesized that natural co...

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Hauptverfasser: Schabowsky, Rich-Henry, Elpek, Kutlu G, Madireddi, Shravan, Sharma, Rajesh K, Yolcu, Esma S., Bandura-Morgan, Laura, Miller, Robert, MacLeod, Kathryn J, Mittler, Robert S., Shirwan, Haval
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2805442/
https://ncbi.nlm.nih.gov/pubmed/19836479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2009.09.127
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