4-1BB ligand as an effective multifunctional immunomodulator and antigen delivery vehicle for the development of therapeutic cancer vaccines

Therapeutic subunit vaccines based on tumor-associated antigens (TAAs) represent an attractive approach for the treatment of cancer. However, poor immunogenicity of TAAs requires potent adjuvants for therapeutic efficacy. We recently proposed the TNF family costimulatory ligands as potential adjuvan...

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Detalhes bibliográficos
Main Authors: Sharma, Rajesh K., Schabowsky, Rich-Henry, Srivastava, Abhishek K., Elpek, Kutlu G., Madireddi, Shravan, Zhao, Hong, Zhong, Zhenping, Miller, Robert W., MacLeod, Kathryn J., Yolcu, Esma S., Shirwan, Haval
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2872136/
https://ncbi.nlm.nih.gov/pubmed/20406989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-4480
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