In vivo Discovery of Immunotherapy Targets in the Tumor Microenvironment

Recent clinical trials showed that targeting of inhibitory receptors on T cells induces durable responses in a subset of cancer patients, despite advanced disease. However, the regulatory switches controlling T cell function in immunosuppressive tumors are not well understood. Here we show that such...

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Detalhes bibliográficos
Main Authors: Zhou, Penghui, Shaffer, Donald R., Arias, Diana A. Alvarez, Nakazaki, Yukoh, Pos, Wouter, Torres, Alexis J., Cremasco, Viviana, Dougan, Stephanie K., Cowley, Glenn S., Elpek, Kutlu, Brogdon, Jennifer, Lamb, John, Turley, Shannon, Ploegh, Hidde L., Root, David E., Love, J. Christopher, Dranoff, Glenn, Hacohen, Nir, Cantor, Harvey, Wucherpfennig, Kai W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4052214/
https://ncbi.nlm.nih.gov/pubmed/24476824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature12988
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