MFG-E8–mediated uptake of apoptotic cells by APCs links the pro- and antiinflammatory activities of GM-CSF

Granulocyte-macrophage colony-stimulating factor (GM-CSF) enhances protection against tumors and infections, but GM-CSF–deficient mice develop inflammatory disease. Here we show that GM-CSF is required for the expression of milk fat globule EGF 8 (MFG-E8) in antigen-presenting cells, and that MFG-E8...

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Main Authors: Jinushi, Masahisa, Nakazaki, Yukoh, Dougan, Michael, Carrasco, Daniel R., Mihm, Martin, Dranoff, Glenn
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2007
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1884688/
https://ncbi.nlm.nih.gov/pubmed/17557120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI30966
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