Tumor Necrosis Factor Receptor-associated Factor 6 (TRAF6) and TGFβ-activated Kinase 1 (TAK1) Play Essential Roles in the C-type Lectin Receptor Signaling in Response to Candida al...

Por Gorjestani, Sara, Darnay, Bryant G., Lin, Xin
Publicado em 2012

Hypoxia-Associated Factor, a Novel E3-Ubiquitin Ligase, Binds and Ubiquitinates Hypoxia-Inducible Factor 1α, Leading to Its Oxygen-Independent Degradation

Por Koh, Mei Yee, Darnay, Bryant G., Powis, Garth
Publicado em 2008

Structural basis for lack of E2 interaction in the RING of TRAF2

Por Yin, Qian, Lamothe, Betty, Darnay, Bryant G., Wu, Hao
Publicado em 2009

TRAF6 and the Three C-Terminal Lysine Sites on IRF7 Are Required for Its Ubiquitination-Mediated Activation by the Tumor Necrosis Factor Receptor Family Member Latent Membrane Prot...

Por Ning, Shunbin, Campos, Alex D., Darnay, Bryant G., Bentz, Gretchen L., Pagano, Joseph S.
Publicado em 2008

TAK1 Is Essential for Osteoclast Differentiation and Is an Important Modulator of Cell Death by Apoptosis and Necroptosis

Por Lamothe, Betty, Lai, YunJu, Xie, Min, Schneider, Michael D., Darnay, Bryant G.
Publicado em 2013

Receptor Activator of Nuclear Factor-κB Ligand-Induced Nuclear Factor of Activated T Cells (C1) Autoregulates Its Own Expression in Osteoclasts and Mediates the Up-Regulation of Ta...

Por Fretz, Jackie A., Shevde, Nirupama K., Singh, Sujay, Darnay, Bryant G., Pike, J. Wesley
Publicado em 2008

The RING Domain and First Zinc Finger of TRAF6 Coordinate Signaling by Interleukin-1, Lipopolysaccharide, and RANKL

Por Lamothe, Betty, Campos, Alejandro D., Webster, William K., Gopinathan, Ambily, Hur, Lana, Darnay, Bryant G.
Publicado em 2008

TRAF6 Ubiquitin Ligase is Essential for RANKL Signaling and Osteoclast Differentiation

Por Lamothe, Betty, Webster, William K., Gopinathan, Ambily, Besse, Arnaud, Campos, Alejandro D., Darnay, Bryant G.
Publicado em 2007

SITE-SPECIFIC LYS-63-LINKED TUMOR NECROSIS FACTOR RECEPTOR-ASSOCIATED FACTOR 6 AUTO-UBIQUITINATION IS A CRITICAL DETERMINANT OF IKK ACTIVATION

Por Lamothe, Betty, Besse, Arnaud, Campos, Alejandro D., Webster, William K., Wu, Hao, Darnay, Bryant G.
Publicado em 2006

The E3 Ubiquitin Ligase TRAF6 Intercedes in Starvation-Induced Skeletal Muscle Atrophy through Multiple Mechanisms

Por Paul, Pradyut K., Bhatnagar, Shephali, Mishra, Vivek, Srivastava, Sanjay, Darnay, Bryant G., Choi, Yongwon, Kumar, Ashok
Publicado em 2012

Targeted ablation of TRAF6 inhibits skeletal muscle wasting in mice

Por Paul, Pradyut K., Gupta, Sanjay K., Bhatnagar, Shephali, Panguluri, Siva K., Darnay, Bryant G., Choi, Yongwon, Kumar, Ashok
Publicado em 2010

NF-κB Signal Triggering and Termination by Tumor Necrosis Factor Receptor 2

Por Rodríguez, Montserrat, Cabal-Hierro, Lucía, Carcedo, María Teresa, Iglesias, Juan Manuel, Artime, Noelia, Darnay, Bryant G., Lazo, Pedro S.
Publicado em 2011

Multiple functions of Osterix are required for bone growth and homeostasis in postnatal mice

Por Zhou, Xin, Zhang, Zhaoping, Feng, Jian Q., Dusevich, Vladmir M., Sinha, Krishna, Zhang, Hua, Darnay, Bryant G., de Crombrugghe, Benoit
Publicado em 2010

TAK1-DEPENDENT SIGNALING REQUIRES FUNCTIONAL INTERACTION WITH TAB2/TAB3

Por Besse, Arnaud, Lamothe, Betty, Campos, Alejandro D., Webster, William K., Maddineni, Upendra, Lin, Su-Chang, Wu, Hao, Darnay, Bryant G.
Publicado em 2006

CARMA3 deficiency abrogates G protein-coupled receptor-induced NF-κB activation

Por Grabiner, Brian C., Blonska, Marzenna, Lin, Pei-Chun, You, Yun, Wang, Donghai, Sun, Jiyuan, Darnay, Bryant G., Dong, Chen, Lin, Xin
Publicado em 2007

Phosphorylation and ubiquitination of the IκB kinase complex by two distinct signaling pathways

Por Shambharkar, Prashant B, Blonska, Marzenna, Pappu, Bhanu P, Li, Hongxiu, You, Yun, Sakurai, Hiroaki, Darnay, Bryant G, Hara, Hiromitsu, Penninger, Josef, Lin, Xin
Publicado em 2007

Molecular Basis for the Unique De-ubiquitinating Activity of the NF-κB Inhibitor A20

Por Lin, Su-Chang, Chung, Jee Y., Lamothe, Betty, Rajashankar, Kanagalaghatta, Lu, Miao, Lo, Yu-Chih, Lam, Amy Y., Darnay, Bryant G., Wu, Hao
Publicado em 2007

Cthrc1 Is a Positive Regulator of Osteoblastic Bone Formation

Por Kimura, Hiroaki, Kwan, Kin Ming, Zhang, Zhaoping, Deng, Jian Min, Darnay, Bryant G., Behringer, Richard R., Nakamura, Takashi, de Crombrugghe, Benoit, Akiyama, Haruhiko
Publicado em 2008

A TRAF2 binding independent region of TNFR2 is responsibl for TRAF2 depletion and enhancement of cytotoxicity driven b TNFR1

Por Cabal-Hierro, Lucía, Noelia, Artime, Iglesias, Julián, Miguel A., Prado, Ugarte-Gil, Lore, Pedro, Casado, Fernández-García, Belén, Darnay, Bryant G., Lazo, Pedro S.
Publicado em 2013

Dasatinib inhibits both osteoclast activation and prostate cancer PC-3 cell-induced osteoclast formation

Por Araujo, John C., Poblenz, Ann, Corn, Paul G., Parikh, Nila U., Starbuck, Michael W., Thompson, Jerry T., Lee, Francis, Logothetis, Christopher J., Darnay, Bryant G.
Publicado em 2009