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TRAF6 Ubiquitin Ligase is Essential for RANKL Signaling and Osteoclast Differentiation
Tumor necrosis factor receptor-associated factor 6 (TRAF6), the crucial adaptor molecule of receptor activator of NF-κB (RANK), plays an essential role in governing the formation of multi-nucleated osteoclasts. TRAF6 is a RING-dependent ubiquitin (Ub) ligase that in conjunction with Ubc13/Uev1A cata...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2732028/ https://ncbi.nlm.nih.gov/pubmed/17572386 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2007.06.017 |
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