The RING Domain and First Zinc Finger of TRAF6 Coordinate Signaling by Interleukin-1, Lipopolysaccharide, and RANKL

TRAF6, a crucial adaptor molecule in innate and adaptive immunity, contains three distinct functional domains. The C-terminal TRAF domain facilitates oligomerization and sequence-specific interaction with receptors or other adaptor proteins. In conjunction with the dimeric E2 enzyme Ubc13-Uev1A, the...

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Detalhes bibliográficos
Main Authors: Lamothe, Betty, Campos, Alejandro D., Webster, William K., Gopinathan, Ambily, Hur, Lana, Darnay, Bryant G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Mechanisms of Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2529010/
https://ncbi.nlm.nih.gov/pubmed/18617513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M802749200
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