Phosphorylation and ubiquitination of the IκB kinase complex by two distinct signaling pathways

The IκB kinase (IKK) complex serves as the master regulator for the activation of NF-κB by various stimuli. It contains two catalytic subunits, IKKα and IKKβ, and a regulatory subunit, IKKγ/NEMO. The activation of IKK complex is dependent on the phosphorylation of IKKα/β at its activation loop and t...

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Detalhes bibliográficos
Main Authors: Shambharkar, Prashant B, Blonska, Marzenna, Pappu, Bhanu P, Li, Hongxiu, You, Yun, Sakurai, Hiroaki, Darnay, Bryant G, Hara, Hiromitsu, Penninger, Josef, Lin, Xin
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1847656/
https://ncbi.nlm.nih.gov/pubmed/17363905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601622
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