Molecular Basis for the Unique De-ubiquitinating Activity of the NF-κB Inhibitor A20

NF-κB activation in the TNF, IL-1 and Toll-like receptor pathways requires Lys63-linked non-degradative polyubiquitination. A20 is a specific feedback inhibitor of NF-κB activation in these pathways and possesses dual ubiquitin editing functions. While the N-terminal domain of A20 is a de-ubiquitina...

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Main Authors: Lin, Su-Chang, Chung, Jee Y., Lamothe, Betty, Rajashankar, Kanagalaghatta, Lu, Miao, Lo, Yu-Chih, Lam, Amy Y., Darnay, Bryant G., Wu, Hao
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2346432/
https://ncbi.nlm.nih.gov/pubmed/18164316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2007.11.092
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