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Inhibition of NF-κB Signaling by A20 Through Disruption of Ubiquitin Enzyme Complexes
A20 negatively regulates inflammation by inhibiting the nuclear factor κB (NF-κB) transcription factor in the tumor necrosis factor receptor (TNFR) and Toll-like receptor (TLR) pathways. A20 contains deubiquitinase and E3 ligase domains and thus has been proposed to function as a ubiquitin-editing e...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3025292/ https://ncbi.nlm.nih.gov/pubmed/20185725 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1182364 |
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