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Regulation of NF-κB signaling by the A20 deubiquitinase
The NF-κB transcription factor is a central mediator of inflammatory and innate immune signaling pathways. Activation of NF-κB is achieved by K63-linked polyubiquitination of key signaling molecules which recruit kinase complexes that in turn activate the IκB kinase (IKK). Ubiquitination is a highly...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2012
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3532050/ https://ncbi.nlm.nih.gov/pubmed/22343828 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cmi.2011.59 |
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