Liver X Receptors as Therapeutic Targets for Managing Cholesterol: Implications for Atherosclerosis and Other Inflammatory Conditions

Por Zhang, Yuan, Chan, Jessica F., Cummins, Carolyn L.
Publicado em 2009

Induction of P-Glycoprotein by Antiretroviral Drugs in Human Brain Microvessel Endothelial Cells

Por Chan, Gary N. Y., Patel, Rucha, Cummins, Carolyn L., Bendayan, Reina
Publicado em 2013

Identification and Quantitation of Sorbitol-Based Nuclear Clarifying Agents Extracted from Common Laboratory and Consumer Plasticware Made of Polypropylene

Por McDonald, Jeffrey G., Cummins, Carolyn L., Barkley, Robert M., Thompson, Bonne M., Lincoln, Holly A.
Publicado em 2008

Synthesis and Activity of Dafachronic Acid Ligands for the C. elegans DAF-12 Nuclear Hormone Receptor

Por Sharma, Kamalesh K., Wang, Zhu, Motola, Daniel L., Cummins, Carolyn L., Mangelsdorf, David J., Auchus, Richard J.
Publicado em 2009

A bile acid-like steroid modulates Caenorhabditis elegans lifespan through nuclear receptor signaling

Por Gerisch, Birgit, Rottiers, Veerle, Li, Dongling, Motola, Daniel L., Cummins, Carolyn L., Lehrach, Hans, Mangelsdorf, David J., Antebi, Adam
Publicado em 2007

A Novel 3-Hydroxysteroid Dehydrogenase That Regulates Reproductive Development and Longevity

Por Wollam, Joshua, Magner, Daniel B., Magomedova, Lilia, Rass, Elisabeth, Shen, Yidong, Rottiers, Veerle, Habermann, Bianca, Cummins, Carolyn L., Antebi, Adam
Publicado em 2012

AKR1B7 Is Induced by the Farnesoid X Receptor and Metabolizes Bile Acids

Por Schmidt, Daniel R., Schmidt, Samuel, Holmstrom, Sam R., Makishima, Makoto, Yu, Ruth T., Cummins, Carolyn L., Mangelsdorf, David J., Kliewer, Steven A.
Publicado em 2011

The Rieske oxygenase DAF-36 functions as a cholesterol 7-desaturase in steroidogenic pathways governing longevity

Por Wollam, Joshua, Magomedova, Lilia, Magner, Daniel B, Shen, Yidong, Rottiers, Veerle, Motola, Daniel L, Mangelsdorf, David J, Cummins, Carolyn L, Antebi, Adam
Publicado em 2011

The small heterodimer partner is a gonadal gatekeeper of sexual maturation in male mice

Por Volle, David H., Duggavathi, Rajesha, Magnier, Benjamin C., Houten, Sander M., Cummins, Carolyn L., Lobaccaro, Jean-Marc A., Verhoeven, Guido, Schoonjans, Kristina, Auwerx, Johan
Publicado em 2007

Liver Receptor Homolog-1 Regulates Bile Acid Homeostasis but Is Not Essential for Feedback Regulation of Bile Acid Synthesis

Por Lee, Youn-Kyoung, Schmidt, Daniel R., Cummins, Carolyn L., Choi, Mihwa, Peng, Li, Zhang, Yuan, Goodwin, Bryan, Hammer, Robert E., Mangelsdorf, David J., Kliewer, Steven A.
Publicado em 2008

Glucocorticoids Regulate the Metabolic Hormone FGF21 in a Feed-Forward Loop

Por Patel, Rucha, Bookout, Angie L., Magomedova, Lilia, Owen, Bryn M., Consiglio, Giulia P., Shimizu, Makoto, Zhang, Yuan, Mangelsdorf, David J., Kliewer, Steven A., Cummins, Carolyn L.
Publicado no Mol Endocrinol (2015)

Loss of the Mono-ADP-ribosyltransferase, Tiparp, Increases Sensitivity to Dioxin-induced Steatohepatitis and Lethality

Por Ahmed, Shaimaa, Bott, Debbie, Gomez, Alvin, Tamblyn, Laura, Rasheed, Adil, Cho, Tiffany, MacPherson, Laura, Sugamori, Kim S., Yang, Yang, Grant, Denis M., Cummins, Carolyn L., Matthews, Jason
Publicado no J Biol Chem (2015)

LXRβ is required for glucocorticoid-induced hyperglycemia and hepatosteatosis in mice

Por Patel, Rucha, Patel, Monika, Tsai, Ricky, Lin, Vicky, Bookout, Angie L., Zhang, Yuan, Magomedova, Lilia, Li, Tingting, Chan, Jessica F., Budd, Conrad, Mangelsdorf, David J., Cummins, Carolyn L.
Publicado em 2010

Liver X receptors regulate adrenal cholesterol balance

Por Cummins, Carolyn L., Volle, David H., Zhang, Yuan, McDonald, Jeffrey G., Sion, Benoît, Lefrançois-Martinez, Anne-Marie, Caira, Françoise, Veyssière, Georges, Mangelsdorf, David J., Lobaccaro, Jean-Marc A.
Publicado em 2006

Lecithin:Cholesterol Acyltransferase Deficiency Protects against Cholesterol-induced Hepatic Endoplasmic Reticulum Stress in Mice

Por Hager, Lauren, Li, Lixin, Pun, Henry, Liu, Lu, Hossain, Mohammad A., Maguire, Graham F., Naples, Mark, Baker, Chris, Magomedova, Lilia, Tam, Jonathan, Adeli, Khosrow, Cummins, Carolyn L., Connelly, Philip W., Ng, Dominic S.
Publicado em 2012

Liver X Receptor Modulates Diabetic Retinopathy Outcome in a Mouse Model of Streptozotocin-Induced Diabetes

Por Hazra, Sugata, Rasheed, Adil, Bhatwadekar, Ashay, Wang, Xiaoxin, Shaw, Lynn C., Patel, Monika, Caballero, Sergio, Magomedova, Lilia, Solis, Nathaniel, Yan, Yuanqing, Wang, Weidong, Thinschmidt, Jeffrey S., Verma, Amrisha, Li, Qiuhong, Levi, Moshe, Cummins, Carolyn L., Grant, Maria B.
Publicado em 2012

Compound prioritization methods increase rates of chemical probe discovery in model organisms

Por Wallace, Iain M, Urbanus, Malene L, Luciani, Genna M, Burns, Andrew R, Han, Mitchell KL, Wang, Hao, Arora, Kriti, Heisler, Lawrence E, Proctor, Michael, St. Onge, Robert P, Roemer, Terry, Roy, Peter J, Cummins, Carolyn L, Bader, Gary D, Nislow, Corey, Giaever, Guri
Publicado em 2011

Mapping the Cellular Response to Small Molecules Using Chemogenomic Fitness Signatures

Por Lee, Anna Y., St.Onge, Robert P., Proctor, Michael J., Wallace, Iain M., Nile, Aaron H., Spagnuolo, Paul A., Jitkova, Yulia, Gronda, Marcela, Wu, Yan, Kim, Moshe K., Cheung-Ong, Kahlin, Torres, Nikko P., Spear, Eric D., Han, Mitchell K. L., Schlecht, Ulrich, Suresh, Sundari, Duby, Geoffrey, Heisler, Lawrence E., Surendra, Anuradha, Fung, Eula, Urbanus, Malene L., Gebbia, Marinella, Lissina, Elena, Miranda, Molly, Chiang, Jennifer H., Aparicio, Ana Maria, Zeghouf, Mahel, Davis, Ronald W., Cherfils, Jacqueline, Boutry, Marc, Kaiser, Chris A., Cummins, Carolyn L., Trimble, William S., Brown, Grant W., Schimmer, Aaron D., Bankaitis, Vytas A., Nislow, Corey, Bader, Gary D., Giaever, Guri
Publicado no Science (2014)