Antifungal Drug Development: Challenges, Unmet Clinical Needs, and New Approaches

Por Roemer, Terry, Krysan, Damian J.
Publicado em 2014

Harnessing the power of transposon mutagenesis for antibacterial target identification and evaluation

Por Meredith, Timothy C., Wang, Hao, Beaulieu, Patrick, Gründling, Angelika, Roemer, Terry
Publicado em 2012

Depletion of the Cullin Cdc53p Induces Morphogenetic Changes in Candida albicans

Por Trunk, Katharina, Gendron, Patrick, Nantel, André, Lemieux, Sébastien, Roemer, Terry, Raymond, Martine
Publicado em 2009

Identification and in vitro Analysis of the GatD/MurT Enzyme-Complex Catalyzing Lipid II Amidation in Staphylococcus aureus

Por Münch, Daniela, Roemer, Terry, Lee, Sang Ho, Engeser, Marianne, Sahl, Hans Georg, Schneider, Tanja
Publicado em 2012

Transcription Factor Substitution during the Evolution of Fungal Ribosome Regulation

Por Hogues, Hervé, Lavoie, Hugo, Sellam, Adnane, Mangos, Maria, Roemer, Terry, Purisima, Enrico, Nantel, André, Whiteway, Malcolm
Publicado em 2008

Global analysis of fungal morphology exposes mechanisms of host cell escape

Por O’Meara, Teresa R., Veri, Amanda O., Ketela, Troy, Jiang, Bo, Roemer, Terry, Cowen, Leah E.
Publicado no Nat Commun (2015)

Pathway analysis of Candida albicans survival and virulence determinants in a murine infection model

Por Becker, Jeffrey M., Kauffman, Sarah J., Hauser, Melinda, Huang, Liyin, Lin, Molly, Sillaots, Susan, Jiang, Bo, Xu, Deming, Roemer, Terry
Publicado em 2010

Atomic resolution mechanistic studies of ribocil: A highly selective unnatural ligand mimic of the E. coli FMN riboswitch

Por Howe, John A., Xiao, Li, Fischmann, Thierry O., Wang, Hao, Tang, Haifeng, Villafania, Artjohn, Zhang, Rumin, Barbieri, Christopher M., Roemer, Terry
Publicado no RNA Biol (2016)

Analysis of the Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrum of Staphylococcus aureus Identifies Mutations That Allow Differentiation of the Main Clonal...

Por Josten, Michaele, Reif, Marion, Szekat, Christiane, Al-Sabti, Nahed, Roemer, Terry, Sparbier, Katrin, Kostrzewa, Markus, Rohde, Holger, Sahl, Hans-Georg, Bierbaum, Gabriele
Publicado em 2013

Essential Gene Identification and Drug Target Prioritization in Aspergillus fumigatus

Por Hu, Wenqi, Sillaots, Susan, Lemieux, Sebastien, Davison, John, Kauffman, Sarah, Breton, Anouk, Linteau, Annie, Xin, Chunlin, Bowman, Joel, Becker, Jeff, Jiang, Bo, Roemer, Terry
Publicado em 2007

Genome-Wide Fitness Test and Mechanism-of-Action Studies of Inhibitory Compounds in Candida albicans

Por Xu, Deming, Jiang, Bo, Ketela, Troy, Lemieux, Sebastien, Veillette, Karynn, Martel, Nick, Davison, John, Sillaots, Susan, Trosok, Steve, Bachewich, Catherine, Bussey, Howard, Youngman, Phil, Roemer, Terry
Publicado em 2007

Staphylococcus aureus Survives with a Minimal Peptidoglycan Synthesis Machine but Sacrifices Virulence and Antibiotic Resistance

Por Reed, Patricia, Atilano, Magda L., Alves, Renato, Hoiczyk, Egbert, Sher, Xinwei, Reichmann, Nathalie T., Pereira, Pedro M., Roemer, Terry, Filipe, Sérgio R., Pereira-Leal, José B., Ligoxygakis, Petros, Pinho, Mariana G.
Publicado no PLoS Pathog (2015)

Chemical Genetic Profiling and Characterization of Small-molecule Compounds That Affect the Biosynthesis of Unsaturated Fatty Acids in Candida albicans

Por Xu, Deming, Sillaots, Susan, Davison, John, Hu, Wenqi, Jiang, Bo, Kauffman, Sarah, Martel, Nick, Ocampo, Pam, Oh, Chanseok, Trosok, Steve, Veillette, Karynn, Wang, Hao, Yang, Minghui, Zhang, Li, Becker, Jeffrey, Martin, Charles E., Roemer, Terry
Publicado em 2009

FtsZ-Dependent Elongation of a Coccoid Bacterium

Por Pereira, Ana R., Hsin, Jen, Król, Ewa, Tavares, Andreia C., Flores, Pierre, Hoiczyk, Egbert, Ng, Natalie, Dajkovic, Alex, Brun, Yves V., VanNieuwenhze, Michael S., Roemer, Terry, Carballido-Lopez, Rut, Scheffers, Dirk-Jan, Huang, Kerwyn Casey, Pinho, Mariana G.
Publicado no mBio (2016)

Compound prioritization methods increase rates of chemical probe discovery in model organisms

Por Wallace, Iain M, Urbanus, Malene L, Luciani, Genna M, Burns, Andrew R, Han, Mitchell KL, Wang, Hao, Arora, Kriti, Heisler, Lawrence E, Proctor, Michael, St. Onge, Robert P, Roemer, Terry, Roy, Peter J, Cummins, Carolyn L, Bader, Gary D, Nislow, Corey, Giaever, Guri
Publicado em 2011

Chemical Genomics-Based Antifungal Drug Discovery: Targeting Glycosylphosphatidylinositol (GPI) Precursor Biosynthesis

Por Mann, Paul A., McLellan, Catherine A., Koseoglu, Sandra, Si, Qian, Kuzmin, Elena, Flattery, Amy, Harris, Guy, Sher, Xinwei, Murgolo, Nicholas, Wang, Hao, Devito, Kristine, de Pedro, Nuria, Genilloud, Olga, Kahn, Jennifer Nielsen, Jiang, Bo, Costanzo, Michael, Boone, Charlie, Garlisi, Charles G., Lindquist, Susan, Roemer, Terry
Publicado no ACS Infect Dis (2014)

The plant defensin RsAFP2 induces cell wall stress, septin mislocalization and accumulation of ceramides in Candida albicans

Por Thevissen, Karin, de Mello Tavares, Patricia, Xu, Deming, Blankenship, Jill, Vandenbosch, Davy, Idkowiak-Baldys, Jolanta, Govaert, Gilmer, Bink, Anna, Rozental, Sonia, de Groot, Piet W.J., Davis, Talya R., Kumamoto, Carol A., Vargas, Gabriele, Nimrichter, Leonardo, Coenye, Tom, Mitchell, Aaron, Roemer, Terry, Hannun, Yusuf A., Cammue, Bruno P.A.
Publicado em 2012

Discovery of Novel Wall Teichoic Acid Inhibitors as Effective anti-MRSA β-lactam Combination Agents

Por Wang, Hao, Gill, Charles J., Lee, Sang H., Mann, Paul, Zuck, Paul, Meredith, Timothy C., Murgolo, Nicholas, She, Xinwei, Kales, Susan, Liang, Lianzhu, Liu, Jenny, Wu, Jin, Maria, John Santa, Su, Jing, Pan, Jianping, Hailey, Judy, Mcguinness, Debra, Tan, Christopher M., Flattery, Amy, Walker, Suzanne, Black, Todd, Roemer, Terry
Publicado em 2013

Chemical Genetic Analysis and Functional Characterization of Staphylococcal Wall Teichoic Acid 2-Epimerases Reveals Unconventional Antibiotic Drug Targets

Por Mann, Paul A., Müller, Anna, Wolff, Kerstin A., Fischmann, Thierry, Wang, Hao, Reed, Patricia, Hou, Yan, Li, Wenjin, Müller, Christa E., Xiao, Jianying, Murgolo, Nicholas, Sher, Xinwei, Mayhood, Todd, Sheth, Payal R., Mirza, Asra, Labroli, Marc, Xiao, Li, McCoy, Mark, Gill, Charles J., Pinho, Mariana G., Schneider, Tanja, Roemer, Terry
Publicado no PLoS Pathog (2016)

Staphylococcus aureus TargetArray: Comprehensive Differential Essential Gene Expression as a Mechanistic Tool To Profile Antibacterials

Por Xu, H. Howard, Trawick, John D., Haselbeck, Robert J., Forsyth, R. Allyn, Yamamoto, Robert T., Archer, Rich, Patterson, Joe, Allen, Molly, Froelich, Jamie M., Taylor, Ian, Nakaji, Danny, Maile, Randy, G. C., Kedar, Pilcher, Marshall, Brown-Driver, Vickie, McCarthy, Melissa, Files, Amy, Robbins, David, King, Paula, Sillaots, Susan, Malone, Cheryl, Zamudio, Carlos S., Roemer, Terry, Wang, Liangsu, Youngman, Philip J., Wall, Daniel
Publicado em 2010