Compound prioritization methods increase rates of chemical probe discovery in model organisms

Pre-selection of compounds that are more likely to induce a phenotype can increase the efficiency and reduce the costs for model organism screening. To identify such molecules, we screened ~81,000 compounds in S. cerevisiae and identified ~7,500 that inhibit cell growth. Screening these growth-inhib...

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Autors principals: Wallace, Iain M, Urbanus, Malene L, Luciani, Genna M, Burns, Andrew R, Han, Mitchell KL, Wang, Hao, Arora, Kriti, Heisler, Lawrence E, Proctor, Michael, St. Onge, Robert P, Roemer, Terry, Roy, Peter J, Cummins, Carolyn L, Bader, Gary D, Nislow, Corey, Giaever, Guri
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4193902/
https://ncbi.nlm.nih.gov/pubmed/22035796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2011.07.018
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