Atomic resolution mechanistic studies of ribocil: A highly selective unnatural ligand mimic of the E. coli FMN riboswitch

Bacterial riboswitches are non-coding RNA structural elements that direct gene expression in numerous metabolic pathways. The key regulatory roles of riboswitches, and the urgent need for new classes of antibiotics to treat multi-drug resistant bacteria, has led to efforts to develop small-molecules...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:RNA Biol
Autori principali: Howe, John A., Xiao, Li, Fischmann, Thierry O., Wang, Hao, Tang, Haifeng, Villafania, Artjohn, Zhang, Rumin, Barbieri, Christopher M., Roemer, Terry
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2016
Soggetti:
Point of View
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5056776/
https://ncbi.nlm.nih.gov/pubmed/27485612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15476286.2016.1216304
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