The plant defensin RsAFP2 induces cell wall stress, septin mislocalization and accumulation of ceramides in Candida albicans

The antifungal plant defensin RsAFP2 isolated from radish interacts with fungal glucosylceramides and induces apoptosis in Candida albicans. To further unravel the mechanism of RsAFP2 antifungal action and tolerance mechanisms, we screened a library of 2,868 heterozygous C. albicans deletion mutants...

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Detalhes bibliográficos
Main Authors: Thevissen, Karin, de Mello Tavares, Patricia, Xu, Deming, Blankenship, Jill, Vandenbosch, Davy, Idkowiak-Baldys, Jolanta, Govaert, Gilmer, Bink, Anna, Rozental, Sonia, de Groot, Piet W.J., Davis, Talya R., Kumamoto, Carol A., Vargas, Gabriele, Nimrichter, Leonardo, Coenye, Tom, Mitchell, Aaron, Roemer, Terry, Hannun, Yusuf A., Cammue, Bruno P.A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3405362/
https://ncbi.nlm.nih.gov/pubmed/22384976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2958.2012.08017.x
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