In Vitro Activity of the Antifungal Plant Defensin RsAFP2 against Candida Isolates and Its In Vivo Efficacy in Prophylactic Murine Models of Candidiasis

We show that RsAFP2, a plant defensin that interacts with fungal glucosylceramides, is active against Candida albicans, inhibits to a lesser extent other Candida species, and is nontoxic to mammalian cells. Moreover, glucosylceramide levels in Candida species correlate with RsAFP2 sensitivity. We fo...

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Detalhes bibliográficos
Main Authors: Tavares, Patricia M., Thevissen, Karin, Cammue, Bruno P. A., François, Isabelle E. J. A., Barreto-Bergter, Eliana, Taborda, Carlos P., Marques, Alexandre F., Rodrigues, Marcio L., Nimrichter, Leonardo
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2592890/
https://ncbi.nlm.nih.gov/pubmed/18824606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00448-08
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