Loss of the Mono-ADP-ribosyltransferase, Tiparp, Increases Sensitivity to Dioxin-induced Steatohepatitis and Lethality

The aryl hydrocarbon receptor (AHR) mediates the toxic effects of the environmental contaminant dioxin (2,3,7,8-tetrachlorodibenzo-p-dioxin; TCDD). Dioxin causes a range of toxic responses, including hepatic damage, steatohepatitis, and a lethal wasting syndrome; however, the mechanisms are still un...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Ahmed, Shaimaa, Bott, Debbie, Gomez, Alvin, Tamblyn, Laura, Rasheed, Adil, Cho, Tiffany, MacPherson, Laura, Sugamori, Kim S., Yang, Yang, Grant, Denis M., Cummins, Carolyn L., Matthews, Jason
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Gene Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4505429/
https://ncbi.nlm.nih.gov/pubmed/25975270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.660100
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