Liver X receptors regulate adrenal cholesterol balance

Cholesterol is the obligate precursor to adrenal steroids but is cytotoxic at high concentrations. Here, we show the role of the liver X receptors (LXRα and LXRβ) in preventing accumulation of free cholesterol in mouse adrenal glands by controlling expression of genes involved in all aspects of chol...

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Detalhes bibliográficos
Main Authors: Cummins, Carolyn L., Volle, David H., Zhang, Yuan, McDonald, Jeffrey G., Sion, Benoît, Lefrançois-Martinez, Anne-Marie, Caira, Françoise, Veyssière, Georges, Mangelsdorf, David J., Lobaccaro, Jean-Marc A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2006
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1483175/
https://ncbi.nlm.nih.gov/pubmed/16823488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI28400
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