Lecithin:Cholesterol Acyltransferase Deficiency Protects against Cholesterol-induced Hepatic Endoplasmic Reticulum Stress in Mice

We recently reported that lecithin:cholesterol acyltransferase (LCAT) knock-out mice, particularly in the LDL receptor knock-out background, are hypersensitive to insulin and resistant to high fat diet-induced insulin resistance (IR) and obesity. We demonstrated that chow-fed Ldlr−/−xLcat+/+ mice ha...

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Detalhes bibliográficos
Main Authors: Hager, Lauren, Li, Lixin, Pun, Henry, Liu, Lu, Hossain, Mohammad A., Maguire, Graham F., Naples, Mark, Baker, Chris, Magomedova, Lilia, Tam, Jonathan, Adeli, Khosrow, Cummins, Carolyn L., Connelly, Philip W., Ng, Dominic S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Lipids
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3370258/
https://ncbi.nlm.nih.gov/pubmed/22500017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.340919
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