AKR1B7 Is Induced by the Farnesoid X Receptor and Metabolizes Bile Acids

Although bile acids are crucial for the absorption of lipophilic nutrients in the intestine, they are cytotoxic at high concentrations and can cause liver damage and promote colorectal carcinogenesis. The farnesoid X receptor (FXR), which is activated by bile acids and abundantly expressed in entero...

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Bibliographische Detailangaben
Hauptverfasser: Schmidt, Daniel R., Schmidt, Samuel, Holmstrom, Sam R., Makishima, Makoto, Yu, Ruth T., Cummins, Carolyn L., Mangelsdorf, David J., Kliewer, Steven A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2011
Schlagworte:
Metabolism
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3024736/
https://ncbi.nlm.nih.gov/pubmed/21081494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.181230
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