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The G Protein-Coupled Bile Acid Receptor, TGR5, Stimulates Gallbladder Filling

TGR5 is a G protein-coupled bile acid receptor present in brown adipose tissue and intestine, where its agonism increases energy expenditure and lowers blood glucose. Thus, it is an attractive drug target for treating human metabolic disease. However, TGR5 is also highly expressed in gallbladder, wh...

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Detalhes bibliográficos
Main Authors: Li, Tingting, Holmstrom, Sam R., Kir, Serkan, Umetani, Michihisa, Schmidt, Daniel R., Kliewer, Steven A., Mangelsdorf, David J.
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3100601/
https://ncbi.nlm.nih.gov/pubmed/21454404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2010-0460
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