The G Protein-Coupled Bile Acid Receptor, TGR5, Stimulates Gallbladder Filling

TGR5 is a G protein-coupled bile acid receptor present in brown adipose tissue and intestine, where its agonism increases energy expenditure and lowers blood glucose. Thus, it is an attractive drug target for treating human metabolic disease. However, TGR5 is also highly expressed in gallbladder, wh...

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Main Authors: Li, Tingting, Holmstrom, Sam R., Kir, Serkan, Umetani, Michihisa, Schmidt, Daniel R., Kliewer, Steven A., Mangelsdorf, David J.
格式: Artigo
語言:Inglês
出版: Endocrine Society 2011
主題:
Original Research
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3100601/
https://ncbi.nlm.nih.gov/pubmed/21454404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2010-0460
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