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A bile acid-like steroid modulates Caenorhabditis elegans lifespan through nuclear receptor signaling
Broad aspects of Caenorhabditis elegans life history, including larval developmental timing, arrest at the dauer diapause, and longevity, are regulated by the nuclear receptor DAF-12. Endogenous DAF-12 ligands are 3-keto bile acid-like steroids, called dafachronic acids, which rescue larval defects...
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| Autors principals: | , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2007
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1821127/ https://ncbi.nlm.nih.gov/pubmed/17360327 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0700847104 |
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