Neuronal Apoptosis Induced by Endoplasmic Reticulum Stress Is Regulated by ATF4–CHOP-Mediated Induction of the Bcl-2 Homology 3-Only Member PUMA

door Galehdar, Zohreh, Swan, Patrick, Fuerth, Benjamin, Callaghan, Steven M., Park, David S., Cregan, Sean P.
Gepubliceerd in J Neurosci (2010)

The JNK- and AKT/GSK3β- Signaling Pathways Converge to Regulate Puma Induction and Neuronal Apoptosis Induced by Trophic Factor Deprivation

door Ambacher, Kristin K., Pitzul, Kristen B., Karajgikar, Meera, Hamilton, Alison, Ferguson, Stephen S., Cregan, Sean P.
Gepubliceerd in 2012

Metabotropic glutamate receptor 5 knockout reduces cognitive impairment and pathogenesis in a mouse model of Alzheimer's disease

door Hamilton, Alison, Esseltine, Jessica L, DeVries, Rebecca A, Cregan, Sean P, Ferguson, Stephen S G
Gepubliceerd in 2014

Role of metabotropic glutamate receptor 5 signaling and homer in oxygen glucose deprivation-mediated astrocyte apoptosis

door Paquet, Maryse, Ribeiro, Fabiola M, Guadagno, Jennifer, Esseltine, Jessica L, Ferguson, Stephen SG, Cregan, Sean P
Gepubliceerd in 2013

Activating transcription factor-4 promotes neuronal death induced by Parkinson’s disease neurotoxins and α-synuclein aggregates

door Demmings, Matthew D., Tennyson, Elizabeth C., Petroff, Gillian N., Tarnowski-Garner, Heather E., Cregan, Sean P.
Gepubliceerd in Cell Death Differ (2020)

Metabotropic Glutamate Receptor-Mediated Cell Signaling Pathways Are Altered in a Mouse Model of Huntington's Disease

door Ribeiro, Fabiola M., Paquet, Maryse, Ferreira, Lucimar T., Cregan, Tamara, Swan, Patrick, Cregan, Sean P., Ferguson, Stephen S. G.
Gepubliceerd in J Neurosci (2010)

Nuclear Factor-κB Modulates the p53 Response in Neurons Exposed to DNA Damage

door Aleyasin, Hossein, Cregan, Sean P., Iyirhiaro, Grace, O'Hare, Michael J., Callaghan, Steve M., Slack, Ruth S., Park, David S.
Gepubliceerd in J Neurosci (2004)

Bax-Dependent Caspase-3 Activation Is a Key Determinant in p53-Induced Apoptosis in Neurons

door Cregan, Sean P., MacLaurin, Jason G., Craig, Constance G., Robertson, George S., Nicholson, Donald W., Park, David S., Slack, Ruth S.
Gepubliceerd in J Neurosci (1999)

Arf6 controls beta-amyloid production by regulating macropinocytosis of the Amyloid Precursor Protein to lysosomes

door Tang, Weihao, Tam, Joshua H.K., Seah, Claudia, Chiu, Justin, Tyrer, Andrea, Cregan, Sean P., Meakin, Susan O., Pasternak, Stephen H.
Gepubliceerd in Mol Brain (2015)

Sertad1 Plays an Essential Role in Developmentaland Pathological Neuron Death

door Biswas, Subhas C., Zhang, Yi, Iyirhiaro, Grace, Willett, Ryan T., Rodriguez Gonzalez, Yasmilde, Cregan, Sean P., Slack, Ruth S., Park, David S., Greene, Lloyd A.
Gepubliceerd in 2010

Rapid and Direct Transport of Cell Surface APP to the Lysosome defines a novel selective pathway

door Lorenzen, Angela, Samosh, Jonathan, Vandewark, Kenneth, Anborgh, Pieter H, Seah, Claudia, Magalhaes, Ana C, Cregan, Sean P, Ferguson, Stephen SG, Pasternak, Stephen H
Gepubliceerd in 2010

Synaptic NMDA receptor activity is coupled to the transcriptional control of the glutathione system

door Baxter, Paul S., Bell, Karen F.S., Hasel, Philip, Kaindl, Angela M., Fricker, Michael, Thomson, Derek, Cregan, Sean P., Gillingwater, Thomas H., Hardingham, Giles E.
Gepubliceerd in Nat Commun (2015)

Corrigendum: Synaptic NMDA receptor activity is coupled to the transcriptional control of the glutathione system

door Baxter, Paul S., Bell, Karen F. S., Hasel, Philip, Kaindl, Angela M., Fricker, Michael, Thomson, Derek., Cregan, Sean P., Gillingwater, Thomas H., Hardingham, Giles E.
Gepubliceerd in Nat Commun (2017)

Role of Spinophilin in Group I Metabotropic Glutamate Receptor Endocytosis, Signaling, and Synaptic Plasticity

door Di Sebastiano, Andrea R., Fahim, Sandra, Dunn, Henry A., Walther, Cornelia, Ribeiro, Fabiola M., Cregan, Sean P., Angers, Stephane, Schmid, Susanne, Ferguson, Stephen S. G.
Gepubliceerd in J Biol Chem (2016)

Puma Is a Dominant Regulator of Oxidative Stress Induced Bax Activation and Neuronal Apoptosis

door Steckley, Diana, Karajgikar, Meera, Dale, Lianne B., Fuerth, Ben, Swan, Patrick, Drummond-Main, Chris, Poulter, Michael O., Ferguson, Stephen S. G., Strasser, Andreas, Cregan, Sean P.
Gepubliceerd in J Neurosci (2007)

p53 Activation Domain 1 Is Essential for PUMA Upregulation and p53-Mediated Neuronal Cell Death

door Cregan, Sean P., Arbour, Nicole A., MacLaurin, Jason G., Callaghan, Steven M., Fortin, Andre, Cheung, Eric C. C., Guberman, Daniel S., Park, David S., Slack, Ruth S.
Gepubliceerd in J Neurosci (2004)

Acidosis overrides oxygen deprivation to maintain mitochondrial function and cell survival

door Khacho, Mireille, Tarabay, Michelle, Patten, David, Khacho, Pamela, MacLaurin, Jason G., Guadagno, Jennifer, Bergeron, Richard, Cregan, Sean P., Harper, Mary-Ellen, Park, David S., Slack, Ruth S.
Gepubliceerd in 2014

APAF1 is a key transcriptional target for p53 in the regulation of neuronal cell death

door Fortin, Andre, Cregan, Sean P., MacLaurin, Jason G., Kushwaha, Neena, Hickman, Emma S., Thompson, Charlie S., Hakim, Antoine, Albert, Paul R., Cecconi, Francesco, Helin, Kristian, Park, David S., Slack, Ruth S.
Gepubliceerd in 2001

Apoptosis-Inducing Factor Is a Key Factor in Neuronal Cell Death Propagated by BAX-Dependent and BAX-Independent Mechanisms

door Cheung, Eric C. C., Melanson-Drapeau, Lysanne, Cregan, Sean P., Vanderluit, Jacqueline L., Ferguson, Kerry L., McIntosh, William C., Park, David S., Bennett, Steffany A. L., Slack, Ruth S.
Gepubliceerd in J Neurosci (2005)

Apoptosis-inducing factor is involved in the regulation of caspase-independent neuronal cell death

door Cregan, Sean P., Fortin, Andre, MacLaurin, Jason G., Callaghan, Steven M., Cecconi, Francesco, Yu, Seong-Woon, Dawson, Ted M., Dawson, Valina L., Park, David S., Kroemer, Guido, Slack, Ruth S.
Gepubliceerd in 2002