Neuronal Apoptosis Induced by Endoplasmic Reticulum Stress Is Regulated by ATF4–CHOP-Mediated Induction of the Bcl-2 Homology 3-Only Member PUMA

An increasing body of evidence points to a key role of endoplasmic reticulum (ER) stress in acute and chronic neurodegenerative conditions. Extensive ER stress can trigger neuronal apoptosis, but the signaling pathways that regulate this cell death remain unclear. In the present study, we demonstrat...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Galehdar, Zohreh, Swan, Patrick, Fuerth, Benjamin, Callaghan, Steven M., Park, David S., Cregan, Sean P.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2010
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6634926/
https://ncbi.nlm.nih.gov/pubmed/21159964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1598-10.2010
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