Metabotropic Glutamate Receptor-Mediated Cell Signaling Pathways Are Altered in a Mouse Model of Huntington's Disease

Huntington's disease (HD) is an autosomal-dominant neurodegenerative disorder caused by a polyglutamine expansion in the huntingtin protein (Htt). Group I metabotropic glutamate receptors (mGluRs) are coupled to G(αq) and play an important role in neuronal survival. We have previously demonstra...

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Publicado en:J Neurosci
Autores principales: Ribeiro, Fabiola M., Paquet, Maryse, Ferreira, Lucimar T., Cregan, Tamara, Swan, Patrick, Cregan, Sean P., Ferguson, Stephen S. G.
Formato: Artigo
Lenguaje:Inglês
Publicado: Society for Neuroscience 2010
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6632544/
https://ncbi.nlm.nih.gov/pubmed/20053912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4974-09.2010
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