Role of metabotropic glutamate receptor 5 signaling and homer in oxygen glucose deprivation-mediated astrocyte apoptosis

BACKGROUND: Group I metabotropic glutamate receptors (mGluR) are coupled via Gα(q/11) to the activation of phospholipase Cβ, which hydrolyzes membrane phospholipids to form inositol 1,4,5 trisphosphate and diacylglycerol. In addition to functioning as neurotransmitter receptors to modulate synaptic...

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Detalhes bibliográficos
Main Authors: Paquet, Maryse, Ribeiro, Fabiola M, Guadagno, Jennifer, Esseltine, Jessica L, Ferguson, Stephen SG, Cregan, Sean P
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3598502/
https://ncbi.nlm.nih.gov/pubmed/23406666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-6606-6-9
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