Neuronal Apoptosis Induced by Endoplasmic Reticulum Stress Is Regulated by ATF4–CHOP-Mediated Induction of the Bcl-2 Homology 3-Only Member PUMA

Por Galehdar, Zohreh, Swan, Patrick, Fuerth, Benjamin, Callaghan, Steven M., Park, David S., Cregan, Sean P.
Publicado no J Neurosci (2010)

The JNK- and AKT/GSK3β- Signaling Pathways Converge to Regulate Puma Induction and Neuronal Apoptosis Induced by Trophic Factor Deprivation

Por Ambacher, Kristin K., Pitzul, Kristen B., Karajgikar, Meera, Hamilton, Alison, Ferguson, Stephen S., Cregan, Sean P.
Publicado em 2012

Metabotropic glutamate receptor 5 knockout reduces cognitive impairment and pathogenesis in a mouse model of Alzheimer's disease

Por Hamilton, Alison, Esseltine, Jessica L, DeVries, Rebecca A, Cregan, Sean P, Ferguson, Stephen S G
Publicado em 2014

Role of metabotropic glutamate receptor 5 signaling and homer in oxygen glucose deprivation-mediated astrocyte apoptosis

Por Paquet, Maryse, Ribeiro, Fabiola M, Guadagno, Jennifer, Esseltine, Jessica L, Ferguson, Stephen SG, Cregan, Sean P
Publicado em 2013

Metabotropic Glutamate Receptor-Mediated Cell Signaling Pathways Are Altered in a Mouse Model of Huntington's Disease

Por Ribeiro, Fabiola M., Paquet, Maryse, Ferreira, Lucimar T., Cregan, Tamara, Swan, Patrick, Cregan, Sean P., Ferguson, Stephen S. G.
Publicado no J Neurosci (2010)

Nuclear Factor-κB Modulates the p53 Response in Neurons Exposed to DNA Damage

Por Aleyasin, Hossein, Cregan, Sean P., Iyirhiaro, Grace, O'Hare, Michael J., Callaghan, Steve M., Slack, Ruth S., Park, David S.
Publicado no J Neurosci (2004)

Bax-Dependent Caspase-3 Activation Is a Key Determinant in p53-Induced Apoptosis in Neurons

Por Cregan, Sean P., MacLaurin, Jason G., Craig, Constance G., Robertson, George S., Nicholson, Donald W., Park, David S., Slack, Ruth S.
Publicado no J Neurosci (1999)

Arf6 controls beta-amyloid production by regulating macropinocytosis of the Amyloid Precursor Protein to lysosomes

Por Tang, Weihao, Tam, Joshua H.K., Seah, Claudia, Chiu, Justin, Tyrer, Andrea, Cregan, Sean P., Meakin, Susan O., Pasternak, Stephen H.
Publicado no Mol Brain (2015)

Sertad1 Plays an Essential Role in Developmentaland Pathological Neuron Death

Por Biswas, Subhas C., Zhang, Yi, Iyirhiaro, Grace, Willett, Ryan T., Rodriguez Gonzalez, Yasmilde, Cregan, Sean P., Slack, Ruth S., Park, David S., Greene, Lloyd A.
Publicado em 2010

Rapid and Direct Transport of Cell Surface APP to the Lysosome defines a novel selective pathway

Por Lorenzen, Angela, Samosh, Jonathan, Vandewark, Kenneth, Anborgh, Pieter H, Seah, Claudia, Magalhaes, Ana C, Cregan, Sean P, Ferguson, Stephen SG, Pasternak, Stephen H
Publicado em 2010

Synaptic NMDA receptor activity is coupled to the transcriptional control of the glutathione system

Por Baxter, Paul S., Bell, Karen F.S., Hasel, Philip, Kaindl, Angela M., Fricker, Michael, Thomson, Derek, Cregan, Sean P., Gillingwater, Thomas H., Hardingham, Giles E.
Publicado no Nat Commun (2015)

Corrigendum: Synaptic NMDA receptor activity is coupled to the transcriptional control of the glutathione system

Por Baxter, Paul S., Bell, Karen F. S., Hasel, Philip, Kaindl, Angela M., Fricker, Michael, Thomson, Derek., Cregan, Sean P., Gillingwater, Thomas H., Hardingham, Giles E.
Publicado no Nat Commun (2017)

Role of Spinophilin in Group I Metabotropic Glutamate Receptor Endocytosis, Signaling, and Synaptic Plasticity

Por Di Sebastiano, Andrea R., Fahim, Sandra, Dunn, Henry A., Walther, Cornelia, Ribeiro, Fabiola M., Cregan, Sean P., Angers, Stephane, Schmid, Susanne, Ferguson, Stephen S. G.
Publicado no J Biol Chem (2016)

Puma Is a Dominant Regulator of Oxidative Stress Induced Bax Activation and Neuronal Apoptosis

Por Steckley, Diana, Karajgikar, Meera, Dale, Lianne B., Fuerth, Ben, Swan, Patrick, Drummond-Main, Chris, Poulter, Michael O., Ferguson, Stephen S. G., Strasser, Andreas, Cregan, Sean P.
Publicado no J Neurosci (2007)

p53 Activation Domain 1 Is Essential for PUMA Upregulation and p53-Mediated Neuronal Cell Death

Por Cregan, Sean P., Arbour, Nicole A., MacLaurin, Jason G., Callaghan, Steven M., Fortin, Andre, Cheung, Eric C. C., Guberman, Daniel S., Park, David S., Slack, Ruth S.
Publicado no J Neurosci (2004)

Acidosis overrides oxygen deprivation to maintain mitochondrial function and cell survival

Por Khacho, Mireille, Tarabay, Michelle, Patten, David, Khacho, Pamela, MacLaurin, Jason G., Guadagno, Jennifer, Bergeron, Richard, Cregan, Sean P., Harper, Mary-Ellen, Park, David S., Slack, Ruth S.
Publicado em 2014

APAF1 is a key transcriptional target for p53 in the regulation of neuronal cell death

Por Fortin, Andre, Cregan, Sean P., MacLaurin, Jason G., Kushwaha, Neena, Hickman, Emma S., Thompson, Charlie S., Hakim, Antoine, Albert, Paul R., Cecconi, Francesco, Helin, Kristian, Park, David S., Slack, Ruth S.
Publicado em 2001

Apoptosis-Inducing Factor Is a Key Factor in Neuronal Cell Death Propagated by BAX-Dependent and BAX-Independent Mechanisms

Por Cheung, Eric C. C., Melanson-Drapeau, Lysanne, Cregan, Sean P., Vanderluit, Jacqueline L., Ferguson, Kerry L., McIntosh, William C., Park, David S., Bennett, Steffany A. L., Slack, Ruth S.
Publicado no J Neurosci (2005)

Apoptosis-inducing factor is involved in the regulation of caspase-independent neuronal cell death

Por Cregan, Sean P., Fortin, Andre, MacLaurin, Jason G., Callaghan, Steven M., Cecconi, Francesco, Yu, Seong-Woon, Dawson, Ted M., Dawson, Valina L., Park, David S., Kroemer, Guido, Slack, Ruth S.
Publicado em 2002

Activating transcription factor 3 promotes loss of the acinar cell phenotype in response to cerulein-induced pancreatitis in mice

Por Fazio, Elena N., Young, Claire C., Toma, Jelena, Levy, Michael, Berger, Kurt R., Johnson, Charis L., Mehmood, Rashid, Swan, Patrick, Chu, Alphonse, Cregan, Sean P., Dilworth, F. Jeffrey, Howlett, Christopher J., Pin, Christopher L.
Publicado no Mol Biol Cell (2017)