Rapid and Direct Transport of Cell Surface APP to the Lysosome defines a novel selective pathway

BACKGROUND: A central feature of Alzheimer's disease is the cleavage of the amyloid precursor protein (APP) to form beta-amyloid peptide (Aβ) by the β-secretase and γ-secretase enzymes. Although this has been shown to occur after endocytosis of APP from the cell surface, the exact compartments...

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Detalhes bibliográficos
Main Authors: Lorenzen, Angela, Samosh, Jonathan, Vandewark, Kenneth, Anborgh, Pieter H, Seah, Claudia, Magalhaes, Ana C, Cregan, Sean P, Ferguson, Stephen SG, Pasternak, Stephen H
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2868040/
https://ncbi.nlm.nih.gov/pubmed/20409323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-6606-3-11
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