Vanadate trapping of nucleotide at the ATP-binding sites of human multidrug resistance P-glycoprotein exposes different residues to the drug-binding site

per Loo, Tip W., Clarke, David M.
Publicat 2002

The PEST sequence does not contribute to the stability of the cystic fibrosis transmembrane conductance regulator

per Chen, Eva Y, Clarke, David M
Publicat 2002

Using a cysteine-less mutant to provide insight into the structure and mechanism of CFTR

per Loo, Tip W, Clarke, David M
Publicat 2006

A Salt Bridge in Intracellular Loop 2 Is Essential for Folding of Human P-Glycoprotein

per Loo, Tip W., Clarke, David M.
Publicat 2013

Drug Rescue Distinguishes between Different Structural Models of Human P-Glycoprotein

per Loo, Tip W., Clarke, David M.
Publicat 2013

Locking Intracellular Helices 2 and 3 Together Inactivates Human P-glycoprotein

per Loo, Tip W., Clarke, David M.
Publicat 2014

Identification of the Distance between the Homologous Halves of P-glycoprotein That Triggers the High/Low ATPase Activity Switch

per Loo, Tip W., Clarke, David M.
Publicat 2014

Cysteines Introduced into Extracellular Loops 1 and 4 of Human P-Glycoprotein That Are Close Only in the Open Conformation Spontaneously Form a Disulfide Bond That Inhibits Drug Ef...

per Loo, Tip W., Clarke, David M.
Publicat 2014

The Transmission Interfaces Contribute Asymmetrically to the Assembly and Activity of Human P-glycoprotein

per Loo, Tip W., Clarke, David M.
Publicat a J Biol Chem (2015)

Mapping the Binding Site of the Inhibitor Tariquidar That Stabilizes the First Transmembrane Domain of P-glycoprotein

per Loo, Tip W., Clarke, David M.
Publicat a J Biol Chem (2015)

Transmembrane segment 1 of human P-glycoprotein contributes to the drug-binding pocket

per Loo, Tip W., Bartlett, M. Claire, Clarke, David M.
Publicat 2006

Transmembrane segment 7 of human P-glycoprotein forms part of the drug-binding pocket

per Loo, Tip W., Bartlett, M. Claire, Clarke, David M.
Publicat 2006

Processing Mutations Disrupt Interactions between the Nucleotide Binding and Transmembrane Domains of P-glycoprotein and the Cystic Fibrosis Transmembrane Conductance Regulator...

per Loo, Tip W., Bartlett, M. Claire, Clarke, David M.
Publicat 2008

Identification of Residues in the Drug Translocation Pathway of the Human Multidrug Resistance P-glycoprotein by Arginine Mutagenesis

per Loo, Tip W., Bartlett, M. Claire, Clarke, David M.
Publicat 2009

The V510D Suppressor Mutation Stabilizes ΔF508-CFTR at the Cell Surface

per Loo, Tip W., Bartlett, M. Claire, Clarke, David M.
Publicat 2010

Benzbromarone Stabilizes ΔF508 CFTR at the Cell Surface

per Loo, Tip W., Bartlett, M. Claire, Clarke, David M.
Publicat 2011

Arginines in the First Transmembrane Segment Promote Maturation of a P-glycoprotein Processing Mutant by Hydrogen Bond Interactions with Tyrosines in Transmembrane Segment 11

per Loo, Tip W., Bartlett, M. Claire, Clarke, David M.
Publicat 2008

Human P-glycoprotein Contains a Greasy Ball-and-Socket Joint at the Second Transmission Interface

per Loo, Tip W., Bartlett, M. Claire, Clarke, David M.
Publicat 2013

Bithiazole Correctors Rescue CFTR Mutants by Two Different Mechanisms

per Loo, Tip W., Bartlett, M. Claire, Clarke, David M.
Publicat 2013

Demoralization, anhedonia and grief in patients with severe physical illness

per CLARKE, DAVID M., KISSANE, DAVID W., TRAUER, TOM, SMITH, GRAEME C.
Publicat 2005