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The V510D Suppressor Mutation Stabilizes ΔF508-CFTR at the Cell Surface
[Image: see text] Deletion of Phe508 (ΔF508) in the first nucleotide-binding domain (NBD1) of CFTR causes cystic fibrosis. The mutation severely reduces the stability and folding of the protein by disrupting interactions between NBD1 and the second transmembrane domain (TMD2). We found that replacem...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Chemical Society
2010
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| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2911077/ https://ncbi.nlm.nih.gov/pubmed/20590134 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi100807h |
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