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Drug Rescue Distinguishes between Different Structural Models of Human P-Glycoprotein

[Image: see text] There is no high-resolution crystal structure of the human P-glycoprotein (P-gp) drug pump. Homology models of human P-gp based on the crystal structures of mouse or Caenorhabditis elegans P-gps show large differences in the orientation of transmembrane segment 5 (TM5). TM5 is one...

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Detalhes bibliográficos
Main Authors: Loo, Tip W., Clarke, David M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2013
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3798097/
https://ncbi.nlm.nih.gov/pubmed/24083983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi401269m
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